MAP3K13

Mitogen-activated protein kinase kinase kinase 13
Identifiers
Symbols	MAP3K13 ; LZK; MEKK13; MLK
External IDs	OMIM: 604915 MGI: 2444243 HomoloGene: 37958 ChEMBL: 1163124 GeneCards: MAP3K13 Gene
EC number	2.7.11.25
Gene ontology Molecular function • protein serine/threonine kinase activity • MAP kinase kinase kinase activity • protein binding • ATP binding • protein kinase binding • identical protein binding • protein homodimerization activity • metal ion binding Cellular component • IkappaB kinase complex • membrane Biological process • activation of MAPKK activity • protein phosphorylation • JNK cascade • protein autophosphorylation • positive regulation of NF-kappaB transcription factor activity Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE MAP3K13 206249 at tn.png
File:PBB GE MAP3K13 211083 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9175	71751
Ensembl	ENSG00000073803	ENSMUSG00000033618
UniProt	O43283	Q1HKZ5
RefSeq (mRNA)	NM_001242314	NM_172821
RefSeq (protein)	NP_001229243	NP_766409
Location (UCSC)	Chr 3: 185.28 – 185.49 Mb	Chr 16: 21.89 – 21.93 Mb
PubMed search	[1]	[2]

Mitogen-activated protein kinase kinase kinase 13 is an enzyme that in humans is encoded by the MAP3K13 gene.

Function

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.

Interactions

MAP3K13 has been shown to interact with PRDX3.