Keratin 1

Keratin 1, type II
Identifiers
Symbols	KRT1 ; CK1; EHK; EHK1; EPPK; K1; KRT1A; NEPPK
External IDs	OMIM: 139350 MGI: 96698 HomoloGene: 38146 GeneCards: KRT1 Gene
Gene ontology Molecular function • receptor activity • structural molecule activity • protein binding • carbohydrate binding Cellular component • extracellular space • nucleus • cytoskeleton • plasma membrane • membrane • extracellular matrix • keratin filament • extracellular exosome • blood microparticle Biological process • complement activation, lectin pathway • retina homeostasis • response to oxidative stress • fibrinolysis • regulation of angiogenesis • negative regulation of inflammatory response • establishment of skin barrier Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3848	16678
Ensembl	ENSG00000167768	ENSMUSG00000046834
UniProt	P04264	P04104
RefSeq (mRNA)	NM_006121	NM_008473
RefSeq (protein)	NP_006112	NP_032499
Location (UCSC)	Chr 12: 52.67 – 52.68 Mb	Chr 15: 101.85 – 101.85 Mb
PubMed search	[1]	[2]

Keratin 1 is a member of the keratin family. It is specifically expressed in the spinous and granular layers of the epidermis with family member keratin 10. Mutations in this gene have been associated with the variants of bullous congenital ichthyosiform erythroderma in which the palms and soles of the feet are affected.

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Interactions

Keratin 1 has been shown to interact with Desmoplakin and PRKCE.

See also

• 34βE12