DNAH11

Dynein, axonemal, heavy chain 11
Identifiers
Symbols	DNAH11 ; CILD7; DNAHBL; DNAHC11; DNHBL; DPL11
External IDs	OMIM: 603339 MGI: 1100864 HomoloGene: 2801 GeneCards: DNAH11 Gene
Gene ontology Molecular function • microtubule motor activity • ATP binding • ATPase activity Cellular component • cytoplasm • microtubule • cilium • dynein complex Biological process • cilium movement • regulation of cilium beat frequency • determination of left/right symmetry • metabolic process • sperm motility Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8701	13411
Ensembl	ENSG00000105877	ENSMUSG00000018581
UniProt	Q96DT5	E9Q7N9
RefSeq (mRNA)	NM_001277115	NM_010060
RefSeq (protein)	NP_001264044	NP_034190
Location (UCSC)	Chr 7: 21.54 – 21.9 Mb	Chr 12: 117.88 – 118.2 Mb
PubMed search	[1]	[2]

Dynein heavy chain 11, axonemal is a protein that in humans is encoded by the DNAH11 gene.

Function

This gene encodes a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing primary ciliary dyskinesia (PCD, formerly called 'immotile cilia syndrome') and Kartagener syndrome (PCD with situs inversus totalis). Males with PCD are not sterile, but are infertile due to lack of sperm motility. There are reports of subfertility and increased risk of ectopic pregnancy in women with PCD.

External links

• GeneReviews/NCBI/NIH/UW entry on Primary Ciliary Dyskinesia