CEP192

Centrosomal protein 192kDa
Identifiers
Symbols	CEP192 ; PPP1R62
External IDs	OMIM: 616426 HomoloGene: 73526 GeneCards: CEP192 Gene
Gene ontology Molecular function • protein binding • phosphatase binding Cellular component • pericentriolar material • cytoplasm • centrosome • centriole • cytosol Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle • organelle organization • negative regulation of phosphatase activity • spindle assembly • centrosome duplication Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55125	70799
Ensembl	ENSG00000101639	ENSMUSG00000024542
UniProt	Q8TEP8	n/a
RefSeq (mRNA)	NM_018069	NM_027556
RefSeq (protein)	NP_115518	NP_081832
Location (UCSC)	Chr 18: 12.99 – 13.13 Mb	Chr 18: 67.8 – 67.89 Mb
PubMed search	[1]	[2]

Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene. It is the homolog of the C. elegans and D. melanogaster gene SPD-2.

Cep192 is a major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells. It stimulates the formation of the scaffolding upon which gamma tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis.