Norbuprenorphine
From Infogalactic: the planetary knowledge core
Systematic (IUPAC) name | |
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(5α,6β,14β,18R)-18-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
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Identifiers | |
CAS Number | 78715-23-8 |
ATC code | None |
PubChem | CID: 114976 |
ChemSpider | 102911 |
Chemical data | |
Formula | C25H35NO4 |
Molecular mass | 413.55 g/mol |
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Norbuprenorphine is a major active metabolite of the opioid modulator buprenorphine. It is a μ-opioid, δ-opioid, and nociceptin receptor full agonist,[1][2] and a κ-opioid receptor partial agonist.[2] In rats, unlike buprenorphine, norbuprenorphine produces marked respiratory depression but with very little antinociceptive effect.[3] In explanation of these properties, norbuprenorphine has been found to be a high affinity P-glycoprotein substrate, and in accordance, shows very limited blood-brain-barrier penetration.[3]
See also
References
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