Isomethadone
Systematic (IUPAC) name | |
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(±)-6-(dimethylamino)-5-methyl-4,4-diphenyl-3-hexanone
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Clinical data | |
Legal status |
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Identifiers | |
CAS Number | 466-40-0 5341-49-1 (HCl) 26594-41-2 ((R)-form) 561-10-4 ((S)-form) 7484-81-2 ((S)-form (HCl)) |
ATC code | None |
PubChem | CID: 10072 |
ChemSpider | 9675 |
UNII | 12L95QD6KV |
Synonyms | WIN-1783, BW 47-442 |
Chemical data | |
Formula | C21H27NO |
Molecular mass | 309.445 g/mol |
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Isomethadone (INN, BAN; Liden), also known as isoamidone, is a synthetic opioid analgesic and antitussive related to methadone that was used formerly as a pharmaceutical drug but is now no longer marketed.[1][2][3][4] Isomethadone was used as both an analgesic and antitussive. It binds to and activates both the μ- and δ-opioid receptors, with the (S)-isomer being the more potent of its two enantiomers.[5] Isomethadone is a Schedule II controlled substance in the United States, with an ACSCN of 9226 and a 2014 aggregate manufacturing quota of 5 grammes. The salts in use are the hydrobromide (free base conversion ratio 0.793), hydrochloride (0.894), and HCl monohydrate (0.850).[6] Isomethadone is also regulated internationally as a Schedule I controlled substance under the United Nations Single Convention on Narcotic Drugs of 1961.[7]
See also
References
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- ↑ http://www.deadiversion.usdoj.gov/fed_regs/quotas/2014/fr0825.htm
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