Teplizumab

From Infogalactic: the planetary knowledge core
Jump to: navigation, search
Teplizumab
Monoclonal antibody
Type Whole antibody
Source Humanized (from mouse)
Target CD3
Identifiers
CAS Number 876387-05-2 N
ATC code none
UNII S4M959U2IJ YesY
Chemical data
Formula C6462H9938N1738O2022S46
Molecular mass 145.8 kg/mol
 NYesY (what is this?)  (verify)

Teplizumab (also known as MGA031 and hOKT3γ1(Ala-Ala)) is a humanized monoclonal antibody that is used as an immunosuppressive drug. The Fc region of this antibody has been engineered to have Fc receptor non-binding (FNB) properties. Teplizumab was originally developed at Columbia University, and was then further developed at MacroGenics, Inc.[1][2]

This antibody has been used in clinical trials with the aim of protecting the remaining β-cells in newly diagnosed type 1 diabetes mellitus patients,[3] but "these agents [i. e. anti-CD3-antibodies] alone do not restore normal glucose control".[4]

Eli Lilly licensed the drug back in 2007 from MacroGenics with a $41 million upfront and a billion dollars pledged for milestones.

It is in Phase-3 clinical trials for Type-1 DM. One-year data from one phase III trial was disappointing.[5]

See also

References

<templatestyles src="Reflist/styles.css" />

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />

External links


<templatestyles src="Asbox/styles.css"></templatestyles>

Stub icon

This monoclonal antibody-related article is a stub. You can help Wikipedia by expanding it.

<templatestyles src="Asbox/styles.css"></templatestyles>

Stub icon

This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.
  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
Retrieved from "https://infogalactic.com/w/index.php?title=Teplizumab&oldid=707386898"