Template:PBB/6041

Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
250px PDB rendering based on 1wdy.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1WDY, 4G8K, 4G8L, 4OAU, 4OAV
Identifiers
Symbols	RNASEL ; PRCA1; RNS4
External IDs	OMIM: 180435 MGI: 1098272 HomoloGene: 8040 ChEMBL: 3575 GeneCards: RNASEL Gene
EC number	3.1.26.-, 3.1.27.-
Gene ontology Molecular function • RNA binding • endoribonuclease activity • protein kinase activity • protein binding • ATP binding • rRNA binding • ribonucleoprotein complex binding • metal ion binding Cellular component • cellular_component • mitochondrial matrix • cytosol • nuclear matrix Biological process • rRNA processing • mRNA processing • protein phosphorylation • cytokine-mediated signaling pathway • regulation of mRNA stability • negative regulation of viral genome replication • fat cell differentiation • positive regulation of transcription from RNA polymerase II promoter • defense response to virus • transmembrane transport • type I interferon signaling pathway • RNA phosphodiester bond hydrolysis, endonucleolytic • positive regulation of glucose import in response to insulin stimulus Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE RNASEL 221287 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6041	24014
Ensembl	ENSG00000135828	ENSMUSG00000066800
UniProt	Q05823	Q05921
RefSeq (mRNA)	NM_021133	NM_011882
RefSeq (protein)	NP_066956	NP_036012
Location (UCSC)	Chr 1: 182.57 – 182.59 Mb	Chr 1: 153.75 – 153.76 Mb
PubMed search	[1]	[2]