Template:PBB/5080

Paired box 6
PDB rendering based on 2cue.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2CUE, 6PAX
Identifiers
Symbols	PAX6 ; AN; AN2; D11S812E; FVH1; MGDA; WAGR
External IDs	OMIM: 607108 MGI: 97490 HomoloGene: 1212 GeneCards: PAX6 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • sequence-specific DNA binding RNA polymerase II transcription factor activity • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription • RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription • DNA binding • chromatin binding • sequence-specific DNA binding transcription factor activity • ubiquitin-protein transferase activity • protein binding • transcription factor binding • protein kinase binding • ubiquitin protein ligase binding • histone acetyltransferase binding • co-SMAD binding • R-SMAD binding • HMG box domain binding Cellular component • nuclear chromatin • nucleus • nucleoplasm • cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • establishment of mitotic spindle orientation • blood vessel development • eye development • cell fate determination • neuron migration • negative regulation of protein phosphorylation • positive regulation of neuroblast proliferation • lens development in camera-type eye • type B pancreatic cell differentiation • pancreatic A cell development • transcription from RNA polymerase II promoter • smoothened signaling pathway • axon guidance • central nervous system development • salivary gland morphogenesis • visual perception • response to wounding • regulation of asymmetric cell division • organ morphogenesis • dorsal/ventral axis specification • positive regulation of gene expression • protein ubiquitination • oligodendrocyte cell fate specification • cerebral cortex regionalization • forebrain anterior/posterior pattern specification • forebrain dorsal/ventral pattern formation • commitment of neuronal cell to specific neuron type in forebrain • forebrain-midbrain boundary formation • regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification • regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification • regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment • pituitary gland development • signal transduction involved in regulation of gene expression • keratinocyte differentiation • regulation of cell migration • positive regulation of epithelial cell differentiation • lacrimal gland development • protein localization to organelle • eye photoreceptor cell development • glucose homeostasis • negative regulation of neuron differentiation • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • regulation of timing of cell differentiation • embryonic camera-type eye morphogenesis • neuron fate commitment • astrocyte differentiation • negative regulation of epithelial cell proliferation • negative regulation of neurogenesis • retina development in camera-type eye • iris morphogenesis • cornea development in camera-type eye • negative regulation of neural precursor cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5080	18508
Ensembl	ENSG00000007372	ENSMUSG00000027168
UniProt	P26367	P63015
RefSeq (mRNA)	NM_000280	NM_001244198
RefSeq (protein)	NP_000271	NP_001231127
Location (UCSC)	Chr 11: 31.78 – 31.82 Mb	Chr 2: 105.67 – 105.7 Mb
PubMed search	[1]	[2]