Template:PBB/3557

Interleukin 1 receptor antagonist
Rendering of 1ILR
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ILR, 1ILT, 1IRA, 1IRP, 1ITN, 2IRT
Identifiers
Symbols	IL1RN ; DIRA; ICIL-1RA; IL-1RN; IL-1ra; IL-1ra3; IL1F3; IL1RA; IRAP; MVCD4
External IDs	OMIM: 147679 MGI: 96547 HomoloGene: 11163 GeneCards: IL1RN Gene
Gene ontology Molecular function • cytokine activity • interleukin-1 receptor binding • interleukin-1, Type I receptor binding • interleukin-1, Type II receptor binding • interleukin-1 receptor antagonist activity • interleukin-1 Type I receptor antagonist activity • interleukin-1 Type II receptor antagonist activity Cellular component • extracellular space • intracellular • cytoplasm • plasma membrane • extracellular exosome Biological process • fever generation • negative regulation of cytokine-mediated signaling pathway • inflammatory response to antigenic stimulus • chronic inflammatory response to antigenic stimulus • lipid metabolic process • acute-phase response • immune response • female pregnancy • memory • negative regulation of glutamate secretion • response to activity • sensory perception of pain • carboxylic acid metabolic process • insulin secretion • negative regulation of cell migration • response to lipopolysaccharide • negative regulation of heterotypic cell-cell adhesion • response to drug • response to starvation • negative regulation of apoptotic process • positive regulation of JUN kinase activity • negative regulation of membrane potential • response to glucocorticoid • response to interleukin-1 • response to interleukin-4 • cellular response to norepinephrine stimulus • negative regulation of interleukin-1-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3557	16181
Ensembl	ENSG00000136689	ENSMUSG00000026981
UniProt	P18510	P25085
RefSeq (mRNA)	NM_000577	NM_001039701
RefSeq (protein)	NP_000568	NP_001034790
Location (UCSC)	Chr 2: 113.11 – 113.13 Mb	Chr 2: 24.34 – 24.35 Mb
PubMed search	[1]	[2]