Robert F. Furchgott

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Robert F. Furchgott
Drfurchgott.jpg
Born Robert Francis Furchgott
June 4, 1916
Charleston, South Carolina
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Seattle, Washington
Citizenship American
Nationality United States
Fields biochemistry
Institutions SUNY Downstate Medical Center 1956–2009
Washington University in St. Louis 1949–1956
Cornell University 1940–1949
Notable awards Nobel Prize in Physiology or Medicine in 1998
Spouse Lenore Mandelbaum (1941–1983; her death; 3 children)
Margaret Gallagher Roth (?–2006; her death)
Signature

Robert Francis Furchgott (June 4, 1916 – May 19, 2009) was a Nobel Prize-winning American biochemist who contributed to the discovery of nitric oxide as a transient cellular signal in mammalian systems.

Early life and education

Lua error in package.lua at line 80: module 'strict' not found. Furchgott was born in Charleston, South Carolina, to Arthur Furchgott (December 1884 – January 1971), a department store owner, and Pena (Sorentrue) Furchgott.[citation needed] He graduated with a degree in chemistry from the University of North Carolina at Chapel Hill (1937),[citation needed] and went on to earn a Ph.D in biochemistry at Northwestern University (1940),[citation needed] immediately joining a medical faculty thereafter.

Career

Lua error in package.lua at line 80: module 'strict' not found. Lua error in package.lua at line 80: module 'strict' not found. Furchgott was faculty member of Cornell University Medical College from 1940 to 1949,[citation needed] of Washington University School of Medicine from 1949 to 1956,[citation needed] and State University of New York Downstate Medical Center from 1956 to 2009, as professor of pharmacology.[citation needed]

In 1978, Furchgott discovered a substance in endothelial cells that relaxes blood vessels, calling it endothelium-derived relaxing factor (EDRF).[citation needed] By 1986, he had worked out EDRF's nature and mechanism of action,[citation needed] and determined that EDRF was in fact nitric oxide (NO),[citation needed] an important compound in many aspects of cardiovascular physiology.[citation needed] This research is important in explaining a wide variety of neuronal, cardiovascular, and general physiologic processed of central importance in human health and disease.[citation needed]

In addition to receiving the Nobel Prize in Physiology or Medicine for the discovery of nitric oxide as a new cellular signal—shared in 1998 with Louis Ignarro and Ferid Murad [1] [2] [3] [4] [5] [6] [7] —Furchgott also received a Gairdner Foundation International Award (1991) for his groundbreaking discoveries,[citation needed] and the Albert Lasker Award for Basic Medical Research (1996), the latter also with Ferid Murad. [8]

Personal life

Furchgott, who was Jewish,[9] lived for most of his married and career life in Woodmere, NY (Long Island). He was married to Lenore Mandelbaum (February 1915 – April 1983)[10] from 1941 until she died aged 68. They had three daughters: Jane, Susan and Terry. His daughter, Susan, was a prolific artist in the San Francisco counter culture and a co-founder of the Kerista Commune (she was also known as "Even Eve" and "Eve Furchgott"). Robert Furchgott later married Margaret Gallagher Roth, who died March 14, 2006.[11] He served as a professor emeritus at the State University of New York Downstate Medical Center. In 2008 he moved to Seattle's Ravenna neighborhood. Furchgott died on May 19, 2009[12] in Seattle. He is survived by his three daughters, four grandchildren, and one great-grandchild.

See also

Further reading

  • Anon. (2009) "Obituary: Robert Furchgott," The Telegraph (online), May 26, 2009, see,[13] accessed 11 August 2015.
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References

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External links

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