RRM2B
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Ribonucleoside-diphosphate reductase subunit M2 B is an enzyme that in humans is encoded by the RRM2B gene.[1][2][3][4] The gene encoding the RRM2B protein is located on chromosome 8, at position 8q23.1. The gene and its products are also known by designations MTDPS8A, MTDPS8B, and p53R2.
Interactions
RRM2B has been shown to interact with Mdm2[5] and Ataxia telangiectasia mutated.[5]
Clinical relevance
Mutations in this gene have been shown to cause progressive external ophthalmoplegia.[6] Increased expression of RRM2B has been correlated with gemcitabine resistance in human cholangiocarcinoma cells[7] and may be predictive of lack of clinical benefit from gemcitabine for human cancers.
References
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