Ribonuclease III
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(Redirected from RNase III)
| Ribonuclease III domain | |||||||||
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Ribonuclease III structure interacting with double stranded RNA.
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| Identifiers | |||||||||
| Symbol | RNase_III | ||||||||
| Pfam | PF00636 | ||||||||
| InterPro | IPR000999 | ||||||||
| PROSITE | PDOC00448 | ||||||||
| SCOP | 1jfz | ||||||||
| SUPERFAMILY | 1jfz | ||||||||
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RNase III is a type of ribonuclease that specifically binds to and cleaves double-stranded RNA (dsRNA).[1] There are four subdivisions, known as Class 1, 2, 3, and 4.
Prokaryotic ribonuclease III (EC 3.1.26.3) (gene rnc)[2] is an enzyme that digests double-stranded RNA. It is involved in the processing of ribosomal RNA precursors and of some mRNAs.
- Class 1 RNases III are largely found in bacteria, bacteriophage, and some fungi. Among the RNases III in the class are the rnc from E. coli, Pac1p from S. pombe, and Rnt1p from S. cerevisiae. Class 1 RNases III process precursors to ribosomal RNA, and in the case of fungi, process precursors to small nuclear RNA (snRNA) and small nucleolar RNA (snoRNA).
- Class 2 RNases III include the Drosha family of enzymes known to function in maturation of precursors to miRNA.[3]
- Class 3 RNases III include the Dicer family of enzymes known to function in RNA interference (RNAi).[4]
- Class 4 RNases III called Mini-III are homodimeric enzymes and consist solely of the RNase III domains.[5]
Human proteins containing this domain
See also
External links
- RNase III at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 3.1.26.3
References
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This article incorporates text from the public domain Pfam and InterPro IPR000999
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