RNF12

Ring finger protein, LIM domain interacting
Identifiers
Symbols	RLIM ; NY-REN-43; RNF12
External IDs	OMIM: 300379 MGI: 1342291 HomoloGene: 7920 GeneCards: RLIM Gene
Gene ontology Molecular function • transcription corepressor activity • ubiquitin-protein transferase activity • zinc ion binding • ligase activity • ubiquitin protein ligase activity Cellular component • nucleus • nucleoplasm • cytoplasm • transcriptional repressor complex Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • ubiquitin-dependent protein catabolic process • protein ubiquitination • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of transcription, DNA-templated • random inactivation of X chromosome Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51132	19820
Ensembl	ENSG00000131263	ENSMUSG00000056537
UniProt	Q9NVW2	Q9WTV7
RefSeq (mRNA)	NM_016120	NM_011276
RefSeq (protein)	NP_057204	NP_035406
Location (UCSC)	Chr X: 74.59 – 74.61 Mb	Chr X: 103.96 – 103.98 Mb
PubMed search	[1]	[2]

E3 ubiquitin-protein ligase RLIM is an enzyme that in humans is encoded by the RLIM gene.

Function

The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported.

Interactions

RNF12 has been shown to interact with Estrogen receptor alpha.