RFFL

Ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
250px PDB rendering based on 1y02.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1Y02
Identifiers
Symbols	RFFL ; CARP-2; CARP2; FRING; RIFIFYLIN; RNF189; RNF34L
External IDs	OMIM: 609735 MGI: 1914588 HomoloGene: 12116 GeneCards: RFFL Gene
Gene ontology Molecular function • protease binding • p53 binding • protein binding • zinc ion binding • ligase activity • protein kinase binding • ubiquitin protein ligase binding • ubiquitin protein ligase activity Cellular component • Golgi membrane • tumor necrosis factor receptor superfamily complex • cytoplasm • lysosome • cytosol • plasma membrane • endosome membrane • membrane • cytoplasmic membrane-bounded vesicle • recycling endosome membrane Biological process • ubiquitin-dependent protein catabolic process • intracellular protein transport • regulation of fibroblast migration • negative regulation of tumor necrosis factor-mediated signaling pathway • regulation of TOR signaling • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process • protein K48-linked ubiquitination • negative regulation of signal transduction by p53 class mediator • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	117584	67338
Ensembl	ENSG00000092871	ENSMUSG00000020696
UniProt	Q8WZ73	Q6ZQM0
RefSeq (mRNA)	NM_001017368	NM_001007465
RefSeq (protein)	NP_001017368	NP_001007466
Location (UCSC)	Chr 17: 35.01 – 35.09 Mb	Chr 11: 82.8 – 82.87 Mb
PubMed search	[1]	[2]

E3 ubiquitin-protein ligase rififylin is an enzyme that in humans is encoded by the RFFL gene.