Pyrin domain
From Infogalactic: the planetary knowledge core
PAAD/DAPIN/Pyrin domain | |||||||||
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File:PDB 1pn5 EBI.jpg | |||||||||
Identifiers | |||||||||
Symbol | PAAD_DAPIN | ||||||||
Pfam | PF02758 | ||||||||
Pfam clan | CL0041 | ||||||||
InterPro | IPR004020 | ||||||||
PROSITE | PS50824 | ||||||||
SCOP | 1pn5 | ||||||||
SUPERFAMILY | 1pn5 | ||||||||
CDD | cd08305 | ||||||||
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A pyrin domain is a protein domain and a subclass of protein motif known as the death fold; it allows a pyrin domain containing protein to interact with other proteins that contain a pyrin domain. It is also known as a PYD or PAAD/DAPIN domain, and is distantly evolutionarily related to the Death domain family of protein domains.[1][2][3]Proteins containing a pyrin domain are frequently involved in biological processes called inflammation and apoptosis.[4][5] Proteins that possess a pyrin domain include intracellular microbial sensors called NOD-like receptors, and proteins associated with their function, such as PYCARD and certain fish caspases.
References
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