Polymeric immunoglobulin receptor

Polymeric immunoglobulin receptor
250px PDB rendering based on 1xed.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1XED, 2OCW, 3CHN, 3CM9
Identifiers
Symbols	PIGR ; FLJ22667; MGC125361; MGC125362
External IDs	OMIM: 173880 MGI: 103080 HomoloGene: 1984 GeneCards: PIGR Gene
Gene ontology Molecular function • polymeric immunoglobulin receptor activity Cellular component • extracellular space • plasma membrane • integral component of plasma membrane • receptor complex • extracellular exosome Biological process • detection of chemical stimulus involved in sensory perception of bitter taste • retina homeostasis • immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor • epidermal growth factor receptor signaling pathway • Fc receptor signaling pathway • receptor clustering Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE PIGR 204213 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5284	18703
Ensembl	ENSG00000162896	ENSMUSG00000026417
UniProt	P01833	O70570
RefSeq (mRNA)	NM_002644	NM_011082
RefSeq (protein)	NP_002635	NP_035212
Location (UCSC)	Chr 1: 206.93 – 206.95 Mb	Chr 1: 130.83 – 130.85 Mb
PubMed search	[1]	[2]

Polymeric immunoglobulin receptor is a protein that in humans is encoded by the PIGR gene. It is a Fc receptor which facilitates the secretion of the soluble polymeric isoforms of immunoglobulin A and immunoglobulin M.

Function

The poly-Ig receptor is expressed on several glandular epithelia including those of liver and breast. It mediates transcellular transport of polymeric immunoglobulin molecules. It is a member of the immunoglobulin superfamily.

Structure

The receptor has 5 units with homology to the variable (V) units of immunoglobulins and a transmembrane region, which also has some homology to certain immunoglobulin variable regions.

External links

• Polymeric Immunoglobulin Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.