Phosphogluconate dehydratase

phosphogluconate dehydratase
Identifiers
EC number	4.2.1.12
CAS number	Template:CAS
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

File:2-keto-3-deoxy-6-phosphogluconate.png

2-keto-3-deoxy-6-phosphogluconate, a product of the reaction catalysed by phosphogluconate dehydratase

In enzymology, a phosphogluconate dehydratase (EC 4.2.1.12) is an enzyme that catalyzes the chemical reaction

6-phospho-D-gluconate $\rightleftharpoons$ 2-dehydro-3-deoxy-6-phospho-D-gluconate + H₂O

Hence, this enzyme has one substrate, 6-phospho-D-gluconate, and two products, 2-dehydro-3-deoxy-6-phospho-D-gluconate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming). Other names in common use include 6-phosphogluconate dehydratase, 6-phosphogluconic dehydrase, gluconate-6-phosphate dehydratase, gluconate 6-phosphate dehydratase, 6-phosphogluconate dehydrase, and 6-phospho-D-gluconate hydro-lyase. This enzyme participates in Entner–Doudoroff pathway.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GP4.