Phenylpiperidine
From Infogalactic: the planetary knowledge core
Phenylpiperidine is a chemical compound with a phenyl moiety directly attached to piperidine. There are a variety of pharmacological effects associated some phenylpiperidines including morphine-like activity[1] or other central nervous system effects.
| Compound | N | 4-position | 3-position | 4'-position | Type of Pharmacology |
| MPPP | Me | Ph | H | -OCOEt | opioid analgesic |
| Prodine | Me | Ph | Me | -OCOEt | opioid analgesic |
| PEPAP | CH2CH2Ph | Ph | H | -OCOMe | opioid analgesic |
| Pethidine | Me | Ph | H | -CO2Et | mu-agonist with SRI properties |
| Budipine | t-Bu | Ph | H | Ph | antiparkinson agent |
| Ketobemidone | Me | 3-HO-Ph | H | -COEt | opioid + NMDA antagonist |
| Paroxetine | H | 4-F-Ph | -CH2OAr | H | SSRI (+ NET) |
| Femoxetine | Me | Ph | -CH2O(4-MeOPh) | H | (S)SRI |
| CPCA | Me | 4-Cl-Ph | -CO2Me | H | monoamine reuptake inhibitor |
Ar = benzodioxol-3-yl
Methylphenidate is a benzylpiperidine.
References
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