mir-192/215 microRNA precursor
| mir-192/215 microRNA precursor | |
|---|---|
 |
|
| Predicted secondary structure and sequence conservation of mir-192 | |
| Identifiers | |
| Symbol | mir-192 |
| Rfam | RF00130 |
| miRBase | MI0000234 |
| miRBase family | MIPF0000063 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Eukaryota |
| GO | 0035195 0035068 |
| SO | 0001244 |
The miR-192 microRNA precursor (homologous to miR-215), is a short non-coding RNA gene involved in gene regulation. miR-192 and miR-215 have now been predicted or experimentally confirmed in mouse and human.[1][2]
microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.[3]
mir-192 and mir-215 are thought to be positive regulators of p53, a human tumour suppressor.[4] They are also overexpressed in gastric cancer, and could be used as biomarkers or therapeutic targets.[5] It has also been suggested that mir-192 could be used as a biomarker for drug-induced liver damage.[6]
References
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