Micro-arrays for mass spectrometry

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Micro-arrays for mass spectrometry (MAMS); introduced by the group of Renato Zenobi in 2010, is an analytical platform for high-throughput analysis of single cells and other low-volume samples by mass spectrometry.[1]

Principle

The mechanism of operation involves unsupervised separating or aliquoting of cell suspensions, or other liquid samples, into discrete recipient sites. The aliquoting effect is achieved due to the differences in wettability of the recipient sites and the surrounding area.[1]

Applications

MAMS are used in single-cell analysis; in particular, single-cell metabolomics.[1][2][3][4][5] Other applications include: interfacing microfluidics,[6] chromatography,[7] and quantitative mass spectrometry.[8]

References

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