MTRR (gene)
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Methionine synthase reductase also known as MSR is an enzyme that in humans is encoded by the MTRR gene.[1][2]
Contents
Function
Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. Methionine synthase reductase regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases.[2]
Clinical significance
Patients of the cblE complementation group of disorders of folate/cobalamin metabolism which results in homocystinuria are defective in reductive activation of methionine synthase.[2]
See also
References
External links
Further reading
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