MDM4
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Protein Mdm4 is a protein that in humans is encoded by the MDM4 gene.[1][2]
Function
The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2[2]
Interactions
MDM4 has been shown to interact with E2F1,[3] Mdm2[4][5][6][7] and P53.[1][6]
References
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