List of U.S. Highways in South Carolina

U.S. Highways of South Carolina
Highway marker for U.S. Highway 76
System information
Maintained by SCDOT
Formed:	November 11, 1926 (1926-11-11)
Highway names
US Routes:	U.S. Highway nn (US nn)
System links
South Carolina Highways Interstate U.S. State Scenic

There are 23 U.S. Highways that exist entirely or partially in the U.S. state of South Carolina. In South Carolina, all U.S. Highways are maintained by the South Carolina Department of Transportation (SCDOT).

U.S. Highways

Route	Southern or western terminus	Northern or eastern terminus	mi	km	Established	Deleted	Description
US 1	Georgia state line at North Augusta	North Carolina state line near Wallace	170.1	273.7	1926	—	Travels north-south along the sandhills region; connecting the cities of North Augusta, Aiken, Columbia, and Camden. South of Camden, it parallels with I-20.
US 15	Walterboro	North Carolina state line at McColl	158.6	255.2	1935	—	Travels north-south, connecting the cities of Walterboro, Sumter, and Bennettsville.
US 17	Georgia state line near Limehouse	North Carolina state line near Little River	221.0	355.7	1927	—	Travels north-south along the coastal plain area, connecting the cities of Hardeeville, Charleston, Georgetown, and Myrtle Beach.
US 21	Hunting Island State Park	North Carolina state line near Little River	232.2	373.7	1926	—	Travels north-south, connecting the cities of Beaufort, Orangeburg, Columbia, and Rock Hill. North of Columbia, it parallels with I-77.
US 25	Georgia state line in North Augusta	North Carolina state line near Travelers Rest	140.3	225.8	1926	—	Travels north-south in the western part of the state, connecting the cities of North Augusta, Greenwood, and Greenville.
US 29	Georgia state line near Holland Store	North Carolina state line at Blacksburg	109.1	175.6	1927	—	Travels north-south in the Upstate area, parallel to I-85. It connects the cities of Anderson, Greenville, and Spartanburg.
US 52	Charleston	North Carolina state line near Cheraw	161.0	259.1	1980s	—	Travels north-south, connecting the cities of Charleston, Lake City, Florence, and Darlington.
US 76	Georgia state line near Westminster	North Carolina state line near Nichols	297.9	479.4	1926	—	Longest US Highway in the state, going east-west; it connects the cities Anderson, Columbia, Sumter, and Florence.
US 78	Georgia state line near North Augusta	Charleston	141.0	226.9	1926	—	Travels east-west, connecting the cities of North Augusta, Aiken, Bamberg, and Charleston.
30px US 117	Conway	North Carolina state line near Little River	45.0	72.4	1932	1935	Replaced by US 501 and US 17.
US 123	Georgia state line near Westminster	Greenville	57.4	92.4	1968	—	Travels north-south in the Upstate area, connecting the cities of Westminster and Greenville.
US 176	North Carolina state line near Landrum	Goose Creek	218.7	352.0	1926	—	Travels east-west, parallel to I-26. It connects the cities of Spartanburg, Union, and Columbia.
US 178	Ridgeville	North Carolina state line near Rocky Bottom	232.7	374.5	1932	—	Travels east-west, connecting the cities of Anderson, Greenwood, and Orangeburg.
US 217	Pee Dee	North Carolina state line near Dillon	24.4	39.3	1927	1932	Replaced by US 301.
US 221	Georgia state line near Clarks Hill	North Carolina state line at Chesnee	125.9	202.6	1932	—	Travels north-south within the Piedmont area, connecting the cities of Greenwood and Spartanburg.
US 276	North Carolina state line near Cleveland	Mauldin	34.2	55.0	1932	—	Shortest US Highway in the state, going east-west; it goes through the city of Greenville.
US 278	Georgia state line near North Augusta	Hilton Head Island	146.0	235.0	1965	—	Travels east-west, connecting the cities of North Augusta and Hilton Head Island.
US 301	Georgia state line near Allendale	North Carolina state line near Dillon	190.3	306.3	1932	—	Travels north-south, loosely parallel to I-95. It connects the cities of Orangeburg, Florence, and Dillon.
US 321	Hardeeville	North Carolina state line near Clover	227.4	366.0	1930	—	Travels north-south, connecting the cities of Hardeeville, Columbia, and York.
US 378	Georgia state line near McCormick	Conway	210.9	339.4	1952	—	Travels east-west, connecting the cities of Columbia, Sumter, and Conway.
US 401	Sumter	North Carolina state line near McColl	77.2	124.2	1957	—	Travels north-south, connecting the cities of Sumter, Darlington, and Bennettsville.
US 501	Myrtle Beach	North Carolina state line near Dillon	74.0	119.1	1935	—	Travels north-south through the Grand Strand area, connecting the cities of Myrtle Beach, Conway, and Dillon.
US 521	Georgetown	North Carolina state line at Indian Land	173.5	279.2	1932	—	Travels north-south, connecting the cities of Georgetown, Sumter, Camden, and Lexington.
US 601	Tarboro	North Carolina state line at Pageland	181.4	291.9	1927	—	Travels north-south,connecting the cities of Bamberg, Orangeburg, Camden, and Pageland.
US 701	Georgetown	North Carolina state line near Loris	61.5	99.0	1932	—	Travels north-south through the Grand Strand area, connecting the cities of Georgetown and Conway.

Alternate routes

Route	Southern or western terminus	Northern or eastern terminus	mi	km	Established	Deleted	Description
US 15 ALT	Walterboro	North Carolina state line near McColl	0	0.0	1937	1946	The entire route was in concurrency with US 15 in South Carolina.
US 15 ALT	Sumter	Society Hill	0	0.0	1955	1957	Replaced by US 401.
US 17 ALT	Georgia state line near Savannah, Georgia	Limehouse	6.7	10.8	1955	1994	Provided an alternate route from Savannah, via the Talmadge Memorial Bridge. Was reassigned as mainline US 17.
US 17 ALT	Pocotaligo	Georgetown	123.4	198.6	1952	—	Travels north-south,connecting the cities of Walterboro, Summerville, Moncks Corner and Georgetown.
25px US 29 ALT	Greenville		0	0.0	1938	1948	Was an alternate route through downtown Greenville, was downgraded to secondary roads.
25px US 29 ALT	Spartanburg	Blacksburg	0	0.0	1955	1962	Was a rebanner of mainline US 29 between Spartanburg and Blacksburg; after I-85 was established, it was reverted to US 29.
30px US 123 ALT	Greenville		0	0.0	1950	1972	Replaced by SC 124.
30px US 176 ALT	Spartanburg		0	0.0	1938	1948	Traversed in downtown Spartanburg, along Magnolia and Howard streets. Some map inserts of the time list it as "Optional US 176;" was downgraded to secondary roads.
US 221 ALT	Chesnee	North Carolina state line near Cowpens National Battlefield	5.3	8.5	1941	—	Provides an alternate route from Chesnee to Forest City, NC.

Business loops

Route	Southern or western terminus	Northern or eastern terminus	mi	km	Established	Deleted	Description
US 15 BUS	Hartsville		6.6	10.6	1969	—	Routed along Fifth Street.
US 15 BUS	Bennettsville		0	0.0	1952	1990	Was routed along Main Street and Tyson Avenue, in concurrency with US 401 Bus. It was replaced by SC 385.
US 17 BUS	Mount Pleasant		4.2	6.8	1967	1992	Was routed along Coleman Boulevard and Georgetown Highway (Chuck Dawley Boulevard) in concurrency with US 701 Bus. It was replaced by SC 703 and BS 526.
US 17 BUS	Murrells Inlet	Myrtle Beach	22.8	36.7	1967	—	Connects the downtown areas of Murrells Inlet, Garden City, Surfside Beach and Myrtle Beach.
US 21 BUS	Beaufort		3.2	5.1	1967	—	Routed along Sea Island Parkway, Carteret Street and Boundary Street.
25px US 21 BUS	Orangeburg		3.3	5.3	1950	1967	Was routed along Broughton Street (in concurrency with US 178 BUS) and Columbia Road.
US 21 BUS	Orangeburg		2.9	4.7	1967	—	Routed along Rowesville Road, Charleston Highway and Magnolia Street.
US 21 BUS	Rock Hill		6.7	10.8	1950	2013	Was routed along Main Street, Albright Road, Black Street, Oakland Avenue, and Cherry Road, through downtown Rock Hill. It was decommissioned at the request of Rock Hill to gain ownership and maintenance oversight.
US 21 BUS	Fort Mill		6.1	9.8	1948	—	It is routed along Spratt Street, White Street, Old Nations Road, and Springfield Parkway, through downtown Fort Mill.
US 25 BUS	Georgia state line in North Augusta		2.8	4.5	1961	—	Only business loop that crosses the Georgia-South Carolina state line.
US 25 BUS	Greenwood		2.8	4.5	1969	—	Notes.
US 25 BUS	Ware Shoals		4.5	7.2	1963	—	Notes.
US 25 BUS	Greenville		0	0.0	1969	1995	Former business loop through downtown Greenville; replaced in parts by US 123, US 276, SC 20 and SC 291.
US 29 BUS	Anderson		6.4	10.3	1947	—	Notes.
25px US 29 BUS	Greenville		0	0.0	1958	1962	Notes.
US 52 BUS	Darlington		4.0	6.4	1974	—	Notes.
US 76 BUS	Seneca		0	0.0	1958	2000	Notes.
US 76 BUS	Laurens		3.8	6.1	1982	—	Notes.
US 76 BUS	Newberry		0	0.0	1952	2001	Notes.
US 76 BUS	Sumter		5.9	9.5	1959	—	Notes.
US 78 BUS	Blackville		0.7	1.1	1981	—	Notes.
US 123 BUS	Seneca		0	0.0	1958	2000	Was routed along North First Street.
30px US 123 BUS	Easley		0	0.0	1958	1964	Was routed along Main Street and Liberty Drive. It was replaced by SC 93.
US 176 BUS	Union		0	0.0	1958	1990	Was routed along Pinckney Street and Thompson Boulevard. It was replaced by SC 18.
US 178 BUS	Greenwood		3.9	6.3	1949	—	Notes.
US 178 BUS	Orangeburg		4.9	7.9	1970	—	Notes.
US 276 BUS	Greenville		0	0.0	1948	1970	Notes.
US 278 BUS	Hilton Head		8.8	14.2	1998	—	Notes.
US 321 BUS	Winnsboro		4.3	6.9	1952	—	Notes.
US 321 BUS	Chester		3.0	4.8	1964	—	Notes.
US 321 BUS	Chester		2.6	4.2	1958	—	Notes.
30px US 378 BUS	Sumter		6.6	10.6	1961	N/A	Was routed along Broad Street, Liberty Street and Myrtle Beach Boulevard.
US 378 BUS	Lake City		2.6	4.2	1958	—	Routed along Main Street (with SC 341) and Church Street/Myrtle Beach Highway.
US 401 BUS	Bennettsville		0	0.0	1958	1990	Was routed along Main Street and Tyson Avenue, in concurrency with US 15 Bus. It was replaced by SC 385.
US 501 BUS	Conway		4.4	7.1	1964	—	Notes.
US 501 BUS	Marion		6.6	10.6	1964	—	Notes.
US 521 BUS	Kershaw		1.4	2.3	N/A	—	Notes.
US 521 BUS	Lancaster		3.8	6.1	1965	—	Notes.
US 701 BUS	Mount Pleasant		4.2	6.8	1967	1992	Was routed along Coleman Boulevard and Georgetown Highway (Chuck Dawley Boulevard) in concurrency with US 17 Bus. It was replaced by SC 703 and BS 526.
US 701 BUS	North Carolina state line near Tabor City, North Carolina		0.1	0.2	1960	—	Only business loop that crosses the North-South Carolina state line.

See also

• South Carolina portal
• U.S. Roads portal

External links

• Media related to at Wikimedia Commons