Lipopolysaccharide binding protein

Lipopolysaccharide binding protein
Identifiers
Symbols	LBP ; BPIFD2
External IDs	OMIM: 151990 MGI: 1098776 HomoloGene: 3055 GeneCards: LBP Gene
Gene ontology Molecular function • lipopolysaccharide binding • receptor binding • protein binding • lipoteichoic acid binding Cellular component • extracellular region • extracellular space • cell surface • extracellular exosome Biological process • liver development • toll-like receptor signaling pathway • leukocyte chemotaxis involved in inflammatory response • macrophage activation involved in immune response • acute-phase response • cellular defense response • opsonization • lipopolysaccharide transport • lipopolysaccharide-mediated signaling pathway • detection of molecule of bacterial origin • response to lipopolysaccharide • negative regulation of tumor necrosis factor production • positive regulation of chemokine production • positive regulation of interleukin-6 production • positive regulation of interleukin-8 production • positive regulation of tumor necrosis factor production • toll-like receptor 4 signaling pathway • positive regulation of toll-like receptor 4 signaling pathway • positive regulation of tumor necrosis factor biosynthetic process • positive regulation of macrophage activation • negative regulation of growth of symbiont in host • innate immune response • defense response to Gram-negative bacterium • defense response to Gram-positive bacterium • positive regulation of phagocytosis, engulfment • positive regulation of respiratory burst involved in inflammatory response • cellular response to lipopolysaccharide • cellular response to lipoteichoic acid • positive regulation of neutrophil chemotaxis • regulation of membrane permeability Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3929	16803
Ensembl	ENSG00000129988	ENSMUSG00000016024
UniProt	P18428	Q61805
RefSeq (mRNA)	NM_004139	NM_008489
RefSeq (protein)	NP_004130	NP_032515
Location (UCSC)	Chr 20: 38.35 – 38.38 Mb	Chr 2: 158.31 – 158.33 Mb
PubMed search	[1]	[2]

Lipopolysaccharide binding protein is a protein that in humans is encoded by the LBP gene.

LBP is a soluble acute-phase protein that binds to bacterial lipopolysaccharide (or LPS) to elicit immune responses by presenting the LPS to important cell surface pattern recognition receptors called CD14 and TLR4.

The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.

Interactions

Lipopolysaccharide-binding protein has been shown to interact with CD14, TLR2, TLR4 and the co-receptor MD-2.

External links

• lipopolysaccharide-binding protein at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.