LMO3

LIM domain only 3 (rhombotin-like 2)
Identifiers
Symbols	LMO3 ; RBTN3; RBTNL2; RHOM3; Rhom-3
External IDs	OMIM: 180386 MGI: 102810 HomoloGene: 136507 GeneCards: LMO3 Gene
Gene ontology Molecular function • protein binding • zinc ion binding Cellular component • cytoplasm Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • positive regulation of peroxisome proliferator activated receptor signaling pathway • positive regulation of fat cell differentiation • negative regulation of ERK1 and ERK2 cascade • positive regulation of glucocorticoid receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE LMO3 204424 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55885	109593
Ensembl	ENSG00000048540	ENSMUSG00000030226
UniProt	Q8TAP4	Q8BZL8
RefSeq (mRNA)	NM_001001395	NM_207222
RefSeq (protein)	NP_001001395	NP_997105
Location (UCSC)	Chr 12: 16.55 – 16.61 Mb	Chr 6: 138.36 – 138.58 Mb
PubMed search	[1]	[2]

LIM domain only protein 3 is a transcription co-factor, which in humans is encoded by the LMO3 gene. LMO3 interacts with the tumor suppressor p53 and regulates its function. LMO3 is considered to be an oncogene in Neuroblastoma.