LDL-receptor-related protein-associated protein

Low density lipoprotein receptor-related protein associated protein 1
PDB rendering based on 1lre.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1LRE, 1NRE, 1OP1, 1OV2, 2FCW, 2FTU, 2FYL, 2P01, 2P03
Identifiers
Symbols	LRPAP1 ; A2MRAP; A2RAP; HBP44; MRAP; MYP23; RAP; alpha-2-MRAP
External IDs	OMIM: 104225 MGI: 96829 HomoloGene: 37612 GeneCards: LRPAP1 Gene
Gene ontology Molecular function • asialoglycoprotein receptor activity • protein binding • heparin binding • lipase binding • receptor antagonist activity • low-density lipoprotein particle receptor binding • unfolded protein binding • very-low-density lipoprotein particle receptor binding Cellular component • extracellular region • endoplasmic reticulum • plasma membrane • cell surface • integral component of membrane • vesicle • rough endoplasmic reticulum lumen Biological process • protein folding • receptor-mediated endocytosis • negative regulation of very-low-density lipoprotein particle clearance • vesicle-mediated transport • negative regulation of protein binding • extracellular negative regulation of signal transduction • negative regulation of beta-amyloid clearance Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4043	16976
Ensembl	ENSG00000163956	ENSMUSG00000029103
UniProt	P30533	P55302
RefSeq (mRNA)	NM_002337	NM_013587
RefSeq (protein)	NP_002328	NP_038615
Location (UCSC)	Chr 4: 3.51 – 3.53 Mb	Chr 5: 35.09 – 35.11 Mb
PubMed search	[1]	[2]

Alpha-2-MRAP_N
haddock model of the complex between double module of lrp, cr56, and first domain of receptor associated protein, rap-d1.
Identifiers
Symbol	Alpha-2-MRAP_N
Pfam	PF06400
InterPro	IPR009066
SCOP	1lre
SUPERFAMILY	1lre
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Alpha-2-MRAP_C
solution structure of domain 3 of rap
Identifiers
Symbol	Alpha-2-MRAP_C
Pfam	PF06401
InterPro	IPR010483
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Low density lipoprotein receptor-related protein-associated protein 1 also known as LRPAP1 or RAP is a chaperone protein which in humans is encoded by the LRPAP1 gene.

Function

LRPAP1 is involved with trafficking of certain members of the LDL receptor family including LRP1 and LRP2. It is a glycoprotein that binds to the alpha-2-macroglobulin receptor, as well as to other members of the low density lipoprotein receptor family. It acts to inhibit the binding of all known ligands for these receptors, and may prevent receptor aggregation and degradation in the endoplasmic reticulum, thereby acting as a molecular chaperone. It may be under the regulatory control of calmodulin, since it is able to bind calmodulin and be phosphorylated by calmodulin-dependent kinase II.

Interactions

LDL-receptor-related protein-associated protein has been shown to interact with LRP2.

External links

• LDL-Receptor Related Protein-Associated Protein at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the public domain Pfam and InterPro IPR010483