Ilepcimide

Ilepcimide
	200px
Systematic (IUPAC) name
	(E)-3-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylprop-2-en-1-one
Identifiers
CAS Number	23434-86-8
ATC code	none
PubChem	CID: 641115
ChemSpider	556435
UNII	5ML58O200F
Chemical data
Formula	C15H17NO3
Molecular mass	259.300 g/mol
	SMILES C1CCN(CC1)C(=O)/C=C/C2=CC3=C(C=C2)OCO3 ;
	InChI InChI=1S/C15H17NO3/c17-15(16-8-2-1-3-9-16)7-5-12-4-6-13-14(10-12)19-11-18-13/h4-7,10H,1-3,8-9,11H2/b7-5+ ; Key:BLPUOQGPBJPXRL-FNORWQNLSA-N ;
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Ilepcimide, also known as antiepilepserine, is a piperidine anticonvulsant.^[1] It was synthesized by Chinese researchers as an analogue of piperine, the main alkaloid and phytochemical of black pepper (and of other plants in the Piperaceae family), which has been used in the treatment of epilepsy in traditional Chinese medicine and as a nerve tonic in traditional Iranian medicine.^[2]

Ilepcimide has serotonergic activity.^[1]^[3]^[4]

Synthesis

Ilepcimide synthesis:^[5]

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↑ Liu, G.Q., Algeria, S., Ceci, A., Gerattini, S., Gobi, M. and Murai, S. (1984) Stimulation of serotonin synthesis in rat brain after antiepilepserine, an antiepileptic piperine derivative. Biochemical Pharmacology 33:3883-3886
↑ Yan, Q.S., Mishra, P.K., Burger, R.L., Bettendorf, A.F., Jobe, P.C. and Dailey J.W. (1992) Evidence that carbamazepine and antiepilepserine may produce a component of their anticonvulsant effects by activating serotonergic neurons in genetically epilepsy-prone rats. J. Pharm & Exp Therap. 261(2):652-659
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