Hydroxylysine
From Infogalactic: the planetary knowledge core
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| Names | |
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| IUPAC name
(2S,5R)-2,6-Diamino-5-hydroxyhexanoic acid
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| Other names
5-Hydroxy-L-lysine,
α,ɛ-diamino-δ-hydroxycaproic acid |
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| Identifiers | |
28902-93-4  |
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| ChemSpider | 10613296 |
| Jmol 3D model | Interactive image |
| MeSH | Hydroxylysine |
| PubChem | 3032849 |
| UNII | 2GQB349IUB |
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| Properties | |
| C6H14N2O3 | |
| Molar mass | 162.187 |
| Vapor pressure | {{{value}}} |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| Infobox references | |
Hydroxylysine (Hyl) is an amino acid with the molecular formula C6H14N2O3. It was first discovered in 1921 by Donald Van Slyke as the 5-Hydroxylysine form.[1] It arises from a post-translational hydroxy modification of lysine. It is most widely known as a component of collagen.[2]
It is biosynthesized from lysine via oxidation by lysyl hydroxylase enzymes. The most common form is the (5R) stereoisomer found in collagen. However, JMJD6 has recently been shown to be a lysyl hydroxylase which modifies an RNA splicing factor producing the (5S) stereoisomer. Additionally, in E. coli, there has been at least one lysine N-hydroxylase enzyme identified, named IucD.[3]
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Hydroxylysine at University of Oulu
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
External links
- Hydroxylysine at the US National Library of Medicine Medical Subject Headings (MeSH)
