Major histocompatibility complex, class II, DQ alpha 1

Major histocompatibility complex, class II, DQ alpha 1, also known as HLA-DQA1, is a human gene present on short arm of chromosome 6 (6p21.3) and also denotes the genetic locus which contains this gene. The protein encoded by this gene is one of two proteins that are required to form the DQ heterodimer, a cell surface receptor essential to the function of the immune system.

Function

HLA-DQA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages).

Gene structure and polymorphisms

The alpha chain contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular protein domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

Alleles

DQ1

There are four commonly encountered DQA1 alleles: DQA1*0101, *0102, *0103, *0104. These alleles are always found in haplotypes with HLA-DQB1*05 (DQ5) and HLA-DQB1*06 (DQ6). DQ1 is a serotype, rare among serotypes for human class II antigens, in that the antibodies to DQ1 react to the alpha chain of HLA DQ, these DQA1 allele gene products.

HLA-DQA1 alleles

	DQA1	linked DQB1 allele
DQ1	*0101	*0501	*0301
	*0102	*0502	*0504	*0602	*0604	*0605	*0609
	*0103	*0501	*0502	*0601	*0602	*0603
	*0104	*0501	*0503	*0602
	*0105	rare
	*0106	rare
See haplotype table in HLA-DQ. Unbolded are rare haplotypes
Link to haplotypes can be followed by DQB1 alleles

Other

The other DQA1 alleles have no defined serotype. There are 5 groups, DQA1*02, *03, *04, *05, *06. DQA1 within these groups are either invariant or produce the same α-chain subunit. DQA1*02 and DQA1*06 contain only one allele. DQA1*03 has three alleles which each produce nearly identical α³. For DQA1*05, the DQA1*0501 and DQA1*0505 produce identical α⁵. Other DQA1*05 exist that produce variant α^5var, but these are rare.

HLA-DQA1 alleles

DQA1	linked DQB1 allele
*0201	*0202	*0303
*0301	*0202	*0302
*0302
*0303	*0301	*0602
*0401	*0303	*0401	*0402
*0501	*0201
*0505	*0301
*0601	*0301
See haplotype table in HLA-DQ. Unbolded are rare haplotypes
Link to haplotypes can be followed by DQB1 alleles

See also

• Major histocompatibility complex
• Human leukocyte antigen
• HLA-DQ