Hydroxyacylglutathione hydrolase
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(Redirected from Glyoxalase II)
| Hydroxyacylglutathione hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.2.6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
|
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In enzymology, a Hydroxyacylglutathione hydrolase (EC 3.1.2.6) is an enzyme that catalyzes the chemical reaction
- (R)-S-lactoylglutathione + water
glutathione + a 2-hydroxy carboxylate
Hence, this enzyme has two substrate, (R)-S-lactoylglutathione and water, and two products, glutathione and a 2-hydroxy carboxylate. With the common substrate methylglyoxal, the product is D-lactate.[1]
This enzyme belongs to the family of hydrolases, specifically the class of thioester lyases. This enzyme is commonly known as glyoxylase II. This enzyme participates in pyruvate metabolism.
References
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