G12/G13 alpha subunits
From Infogalactic: the planetary knowledge core
| guanine nucleotide-binding protein (G protein) alpha 12 | |
|---|---|
| Identifiers | |
| Symbol | GNA12 |
| Entrez | 2768 |
| HUGO | 4380 |
| OMIM | 604394 |
| RefSeq | NM_007353 |
| UniProt | Q03113 |
| Other data | |
| Locus | Chr. 7 p22.3 |
| guanine nucleotide-binding protein (G protein), alpha 13 | |
|---|---|
| Identifiers | |
| Symbol | GNA13 |
| Entrez | 10672 |
| HUGO | 4381 |
| OMIM | 604406 |
| RefSeq | NM_006572 |
| UniProt | Q14344 |
| Other data | |
| Locus | Chr. 17 q24 |
G12/G13 subunits are alpha units of heterotrimeric G proteins that regulate cell processes through the use of guanine nucleotide exchange factors.[1] These two subunits represent a fourth class of G protein alpha subunits.[2] They are not sensitive to pertussis toxin.[3]
G proteins G12 and G13 regulate actin cytoskeletal remodeling in cells.[4] G13 is also essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells.[5]
Genes
References
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<references />, or <references group="..." />External links
- GTP-Binding Protein alpha Subunits, G12-G13 at the US National Library of Medicine Medical Subject Headings (MeSH)
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