EPS8L1

EPS8-like 1
250px PDB rendering based on 2cy4.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2K2M, 2ROL
Identifiers
Symbols	EPS8L1 ; DRC3; EPS8R1; PP10566
External IDs	OMIM: 614987 MGI: 1914675 HomoloGene: 15767 GeneCards: EPS8L1 Gene
Gene ontology Molecular function • actin binding • Rho guanyl-nucleotide exchange factor activity • protein binding • Rac guanyl-nucleotide exchange factor activity • T cell receptor binding Cellular component • cytoplasm • ruffle membrane • protein complex • extracellular exosome Biological process • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of GTPase activity • positive regulation of ruffle assembly Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE EPS8L1 218778 x at tn.png
File:PBB GE EPS8L1 218779 x at tn.png
File:PBB GE EPS8L1 221655 x at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54869	67425
Ensembl	ENSG00000131037	ENSMUSG00000006154
UniProt	Q8TE68	Q8R5F8
RefSeq (mRNA)	NM_017729	NM_001290416
RefSeq (protein)	NP_060199	NP_001277345
Location (UCSC)	Chr 19: 55.07 – 55.09 Mb	Chr 7: 4.46 – 4.48 Mb
PubMed search	[1]	[2]

Epidermal growth factor receptor kinase substrate 8-like protein 1 is an enzyme that in humans is encoded by the EPS8L1 gene.

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Several alternatively spliced transcript variants encoding different isoforms exist.