Dyclonine

Dyclonine

Systematic (IUPAC) name
1-(4-butoxyphenyl)-3-(1-piperidyl)propan-1-one
Clinical data
Trade names	Sucrets
AHFS/Drugs.com	monograph
Pregnancy category	US: C (Risk not ruled out)
Legal status	US: OTC
Routes of administration	Lozenge
Identifiers
CAS Number	586-60-7 Y
ATC code	N01BX02 (WHO) R02AD04
PubChem	CID: 3180
IUPHAR/BPS	7173
DrugBank	DB00645 Y
ChemSpider	3068 Y
UNII	078A24Q30O Y
KEGG	D07881 Y
ChEBI	CHEBI:4724 Y
ChEMBL	CHEMBL1201217 N
Chemical data
Formula	C18H27NO2
Molecular mass	289.413 g/mol
SMILES O=C(c1ccc(OCCCC)cc1)CCN2CCCCC2
InChI InChI=1S/C18H27NO2/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19/h7-10H,2-6,11-15H2,1H3 Y Key:BZEWSEKUUPWQDQ-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Dyclonine is an oral anaesthetic that is the active ingredient of Sucrets, an over the counter throat lozenge. It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt.

History

The product Sucrets was introduced in Baltimore, Maryland, by Sharp & Dohme in 1932.

In 1966 the Federal Trade Commission ordered Merck and Company to discontinue the false claims of germ-killing and pain-relieving properties for its Sucrets and Children's Sucrets throat lozenges. In 1977, it was acquired by Beecham, later merging with SmithKline Beckman in 1989 to form SmithKline Beecham. By 1994 the brand switched from a metal container to a plastic container. SmithKline Beecham, after announcing a merger with GlaxoWellcome to form GlaxoSmithKline, sold the brand in 2000 to Insight Pharmaceuticals. In 2011, Sucrets reintroduced their product back into the familiar tin due to popular demand and nostalgia.

External links

• Sucrets: Our heritage