Contryphan
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The contryphans (conus + tryptophan) are a family of peptides that are active constituents of the potent venom produced by cone snail (genus conus). The two amino acid cysteine residues in contryphans are linked by a disulfide bond. In addition, contryphans undergo an unusual degree of post-translational modification including epimerization of leucine and tryptophan, tryptophan bromination, amidation of the C-terminus, and proline hydroxylation.[2]
Family members
Contryphan family members include:
| Peptide | Sequence | Species | Reference |
|---|---|---|---|
| Des(Gly1)contryphan-R | COwEPWC-NH2 | C. radiatus | [3] |
| Contryphan-R | GCOwEPWC-NH2 | Conus radiatus | [3] |
| Bromocontyphan-R | GCOwEPXC-NH2 | C. radiatus | [4] |
| Contryphan-Sm | GCOwQPWC-NH2 | Conus stercusmuscarum | [5] |
| Contryphan-P | GCOwDPWC-NH2 | C. purpurascens | [5] |
| Contryphan-R/Tx | GCOwEPWC-NH2 | Conus textile | [5] |
| Contryphan-Tx | GCOWQPYC-NH2 | Conus textile | [5] |
| Contryphan-Vn | GDCPwKPWC-NH2 | Conus ventricosus | [6] |
| Leu-contryphan-P | GCVlLPWC-OH | Conus purpurascens | [7] |
| Leu-contryphan-Tx | CVlYPWC-NH2 | Conus textile | [5] |
| Glaconryphan-M | NγSγCPWHPWC-NH2 | Conus marmoreus | [2] |
where the sequence abbreviations stand for:
- O = 4-trans-hydroxyproline,
- l = D-leucine, L = L-leucine,
- w = D-tryptophan, W = L-tryptophan,
- γ = gamma-carboxyglutamic acid,
- NH2 = C-terminal amidation
and the remainder of the letters refer to the standard one letter abbreviations for amino acids.
Mechanism of toxicity
The venom of cone snails cause paralysis of their fish prey. The molecular target has not been determined for all contryphan peptides, however it is known that contryphan-Vn is a Ca2+-dependent K+ channel modulator,[6] while glacontryphan-M is a L-type calcium channel blocker.[2]
See also
References
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<references />, or <references group="..." />External links
- Contryphan at the US National Library of Medicine Medical Subject Headings (MeSH)
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- ↑ PDB: 1NXN; Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 2.0 2.1 2.2 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 3.0 3.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 5.0 5.1 5.2 5.3 5.4 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 6.0 6.1 Lua error in package.lua at line 80: module 'strict' not found.
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