Complement component 4
From Infogalactic: the planetary knowledge core
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It is cleaved into proteins 4a and 4b; 4b can be further cleaved into 4c and 4d.[1]
- C4a is an anaphylatoxin.
- C4b forms part of C3-convertase, in conjunction with 2a:
- C4b can bind CR1.
File:Droga klasyczna.png
Classical pathway. (Some labels are in Polish.)
Clinical significance
It is responsible for the Chido Rodgers blood group system.[2]
C4d has been identified as a biomarker for systemic lupus erythematosus.[3]
References
- ↑ http://www.immunologyreport.com/ATC2013/pdf/MacConmara.pdf
- ↑ Chido Rodgers blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
