Ciraparantag
Lua error in Module:Infobox at line 314: malformed pattern (missing ']'). Ciraparantag (INN/USAN, or aripazine) is a drug under investigation as an antidote for a number of anticoagulant (anti–blood clotting) drugs, including factor Xa inhibitors (rivaroxaban, apixaban and edoxaban), dabigatran, low molecular weight heparins and unfractionated heparin.[1][2]
Contents
Mechanism of action
According to in vitro studies, the substance binds directly to anticoagulants via hydrogen bonds from or to various parts of the molecule:[1]
Hydrogen bonds | Rivaroxaban | Apixaban | Edoxaban | Dabigatran | Heparins |
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Guanidine part | ![]() |
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α-Amino group | ![]() |
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Amide nitrogen | ![]() |
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Amide oxygen | ![]() |
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Chemical properties
Ciraparantag consists of two L-arginine units connected with a piperazine containing linker chain.[1]
See also
Other anticoagulant antidotes
References
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