Ciraparantag

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Lua error in Module:Infobox at line 314: malformed pattern (missing ']'). Ciraparantag (INN/USAN, or aripazine) is a drug under investigation as an antidote for a number of anticoagulant (anti–blood clotting) drugs, including factor Xa inhibitors (rivaroxaban, apixaban and edoxaban), dabigatran, low molecular weight heparins and unfractionated heparin.[1][2]

Mechanism of action

According to in vitro studies, the substance binds directly to anticoagulants via hydrogen bonds from or to various parts of the molecule:[1]

Hydrogen bonds Rivaroxaban Apixaban Edoxaban Dabigatran Heparins
Guanidine part Green tickY Green tickY Green tickY Green tickY
α-Amino group Green tickY Green tickY Green tickY Green tickY
Amide nitrogen Green tickY Green tickY Green tickY
Amide oxygen Green tickY Green tickY

Chemical properties

Ciraparantag consists of two L-arginine units connected with a piperazine containing linker chain.[1]

See also

Other anticoagulant antidotes

References

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  1. 1.0 1.1 1.2 Schubert-Zsilavecz, M, Wurglics, M, Neue Arzneimittel Herbst 2015 (German)
  2. Lua error in package.lua at line 80: module 'strict' not found.