Cbl TKB domain

In molecular biology, the Cbl TKB domain (tyrosine kinase binding domain), also known as the phosphotyrosine binding (PTB) domain is a conserved region found at the N-terminus of Cbl adaptor proteins. This N-terminal region is composed of three evolutionarily conserved domains: an N-terminal four-helix bundle domain, an EF hand-like domain and a SH2-like domain, which together are known to bind to phosphorylated tyrosine residues.

References

This article incorporates text from the public domain Pfam and InterPro IPR014742

This article incorporates text from the public domain Pfam and InterPro IPR014741

This article incorporates text from the public domain Pfam and InterPro IPR003153