Casein kinase 2, alpha 1

See also: Casein kinase 2

Casein kinase 2, alpha 1 polypeptide
250px PDB rendering based on 1jwh.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1JWH, 1NA7, 1PJK, 2PVR, 2ZJW, 3AMY, 3AT2, 3AT3, 3AT4, 3AXW, 3BQC, 3C13, 3FWQ, 3H30, 3JUH, 3MB6, 3MB7, 3NGA, 3NSZ, 3OWJ, 3OWK, 3OWL, 3PE1, 3PE2, 3PE4, 3Q04, 3Q9W, 3Q9X, 3Q9Y, 3Q9Z, 3QA0, 3R0T, 3RPS, 3TAX, 3U4U, 3U87, 3U9C, 3W8L, 3WAR, 3WIK, 3WIL, 3WOW, 4BXA, 4BXB, 4DGL, 4FBX, 4GRB, 4GUB, 4GYW, 4GYY, 4GZ3, 4IB5, 4KWP, 4MD7, 4MD8, 4MD9, 4NH1, 4RLL
Identifiers
Symbols	CSNK2A1 ; CK2A1; CKII; CSNK2A3
External IDs	OMIM: 115440 MGI: 88543 HomoloGene: 90874 ChEMBL: 3629 GeneCards: CSNK2A1 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • protein binding • ATP binding • protein N-terminus binding • Hsp90 protein binding Cellular component • nucleus • cytosol • plasma membrane • Sin3 complex • NuRD complex • PcG protein complex Biological process • mitotic cell cycle • transcription, DNA-templated • regulation of transcription, DNA-templated • protein phosphorylation • signal transduction • axon guidance • positive regulation of cell proliferation • Wnt signaling pathway • positive regulation of Wnt signaling pathway • positive regulation of cell growth • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of protein catabolic process • rhythmic process • chaperone-mediated protein folding • mitotic spindle checkpoint Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CSNK2A1 212072 s at tn.png
File:PBB GE CSNK2A1 206075 s at tn.png
File:PBB GE CSNK2A1 212073 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1457	12995
Ensembl	ENSG00000101266	ENSMUSG00000074698
UniProt	P68400	Q60737
RefSeq (mRNA)	NM_001895	NM_007788
RefSeq (protein)	NP_001886	NP_031814
Location (UCSC)	Chr 20: 0.47 – 0.54 Mb	Chr 2: 152.23 – 152.28 Mb
PubMed search	[1]	[2]

Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A1 gene.

Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.

Interactions

Casein kinase 2, alpha 1 has been shown to interact with:

• APC,
• ATF1,
• ATF2,
• C-Fos,
• C-jun,
• CDC25B,
• CHEK1,
• CREBBP,
• CSNK2B,
• DDIT3,
• FGF1,
• FGF2,
• HNRPA2B1
• MAPK14,
• PIN1,
• PLEKHO1,
• PTEN,
• RELA,
• TAF1, and
• UBTF.