Carbamoyl phosphate

Carbamoyl phosphate

Names
IUPAC name (Carbamoyloxy)phosphonic acid
Identifiers
CAS Number	590-55-6 Y
ChEBI	CHEBI:17672 N
ChEMBL	ChEMBL369105 N
ChemSpider	272 N
Jmol 3D model	Interactive image
KEGG	C00169 N
MeSH	Carbamoyl+phosphate
PubChem	278
InChI InChI=1S/CH4NO5P/c2-1(3)7-8(4,5)6/h(H2,2,3)(H2,4,5,6) Key: FFQKYPRQEYGKAF-UHFFFAOYSA-N
SMILES C(=O)(N)OP(=O)(O)O
Properties
Chemical formula	CH2NO5P2−
Molar mass	141.020 g/mol
Vapor pressure	{{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Carbamoyl phosphate is an anion of biochemical significance. In land-dwelling animals, it is an intermediary metabolite in nitrogen disposal through the urea cycle and the synthesis of pyrimidines.

Production

It is produced from bicarbonate, ammonia (derived from glutamine), and phosphate (from ATP). The synthesis is catalysed by the enzyme carbamoyl phosphate synthetase, as follows:

• HCO₃⁻ + ATP → ADP + HO–C(O)–OPO₃²⁻ (carboxyl phosphate)
• HO–C(O)–OPO₃²⁻ + NH₃ + OH⁻ → HPO₄²⁻ + ⁻O–C(O)NH₂ + H₂O
• ⁻O–C(O)NH₂ + ATP → ADP + H₂NC(O)OPO₃²⁻

See also

• Ornithine transcarbamylase