Caldesmon

Caldesmon 1
Identifiers
Symbols	CALD1 ; CDM; H-CAD; HCAD; L-CAD; LCAD; NAG22
External IDs	OMIM: 114213 HomoloGene: 137424 GeneCards: CALD1 Gene
Gene ontology Molecular function • actin binding • calmodulin binding • tropomyosin binding • myosin binding Cellular component • cytosol • cytoskeleton • plasma membrane • actin cytoskeleton • myofibril • actin cap Biological process • movement of cell or subcellular component • muscle contraction Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CALD1 201616 s at tn.png
File:PBB GE CALD1 201615 x at tn.png
File:PBB GE CALD1 201617 x at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	800	n/a
Ensembl	ENSG00000122786	n/a
UniProt	Q05682	n/a
RefSeq (mRNA)	NM_004342	n/a
RefSeq (protein)	NP_004333	n/a
Location (UCSC)	Chr 7: 134.74 – 134.97 Mb	n/a
PubMed search	[1]	n/a

Caldesmon is a protein that in humans is encoded by the CALD1 gene.

Caldesmon is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle.

This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca⁺⁺-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca⁺⁺-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Immunochemistry

In diagnostic immunochemistry, caldesmon is a marker for smooth muscle differentiation.

External links

• Caldesmon at the US National Library of Medicine Medical Subject Headings (MeSH)