25-Hydroxyvitamin D3 1-alpha-hydroxylase

25-Hydroxyvitamin D₃ 1-alpha-hydroxylase (VD3 1A hydroxylase) also known as cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a cytochrome P450 enzyme that in humans is encoded by the CYP27B1 gene.

VD3 1A hydroxylase is located in the proximal tubule of the kidney and a variety of other tissues, including skin (keratinocytes), immune cells, and bone (osteoblasts). The enzyme catalyzes the hydroxylation of Calcifediol to calcitriol (the bioactive form of Vitamin D):

calcidiol + NADPH + H⁺ + O₂ $\rightleftharpoons$ calcitriol + NADP⁺ + H₂O

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  Calcidiol

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  Calcitriol

calcidiol 1-monooxygenase Identifiers EC number 1.14.13.13 CAS number Template:CAS Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles NCBI proteins

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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|{{{bSize}}}px|alt=Vitamin D Synthesis Pathway edit]]

File:VitaminDSynthesis WP1531.png

Vitamin D Synthesis Pathway edit

External links

• 25-Hydroxyvitamin D3 1-alpha-Hydroxylase at the US National Library of Medicine Medical Subject Headings (MeSH)