CAPN9

Calpain 9
250px PDB rendering based on 1ziv.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ZIV, 2P0R
Identifiers
Symbols	CAPN9 ; GC36; nCL-4
External IDs	OMIM: 606401 MGI: 1920897 HomoloGene: 38208 GeneCards: CAPN9 Gene
EC number	3.4.22.-
Gene ontology Molecular function • calcium-dependent cysteine-type endopeptidase activity • calcium ion binding Cellular component • cellular_component • cytoplasm Biological process • proteolysis • digestion Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CAPN9 210641 at tn.png
File:PBB GE CAPN9 208063 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10753	73647
Ensembl	ENSG00000135773	ENSMUSG00000031981
UniProt	O14815	Q9D805
RefSeq (mRNA)	NM_006615	NM_023709
RefSeq (protein)	NP_006606	NP_076198
Location (UCSC)	Chr 1: 230.75 – 230.8 Mb	Chr 8: 124.58 – 124.62 Mb
PubMed search	[1]	[2]

Calpain-9 is a protein that in humans is encoded by the CAPN9 gene.

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

External links

• The MEROPS online database for peptidases and their inhibitors: C02.006