Buparlisib
From Infogalactic: the planetary knowledge core
| 175px | |
| Systematic (IUPAC) name | |
|---|---|
|
5-[2,6-bis(morpholin-4-yl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine
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| Identifiers | |
| ATC code | None |
| PubChem | CID: 16654980 |
| ChemSpider | 17588300 |
| KEGG | D10584 |
| Chemical data | |
| Formula | C18H21F3N6O2 |
| Molecular mass | 410.39 g/mol |
Buparlisib (INN,[1] codenamed BKM120) is an investigational small molecule orally-available pan-class I phosphoinositide 3-kinase inhibitor.[2]
Clinical trials
In December 2015 it is reporting results for the phase III BELLE-2 clinical trial for advanced HR+/HER2 endocrine-resistant breast cancer.[3] Encouraging results are reported in some sub-populations — eg., some PI3K mutations.[3][4]
See also
References
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<references />, or <references group="..." />External links
- Buparlisib Shows Promise in Metastatic Breast Cancer. Aug 2014 Buparlisib combined with letrozole
- Phase II Study of Buparlisib + Docetaxel in Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) Patients completed
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This pharmacology-related article is a stub. You can help Wikipedia by expanding it. |
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 3.0 3.1 PI3K Inhibitor Penetrates Endocrine-Resistant Breast Cancer. Dec 2015
- ↑ Buparlisib Benefits Women With PIK3CA Mutations in Circulating Tumor DNA. Dec 2015
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