Beta-mannosidase

For other uses of the term "MANBA", see Manba (disambiguation).

Mannosidase, beta A, lysosomal
Identifiers
Symbols	MANBA ; MANB1
External IDs	OMIM: 609489 MGI: 88175 HomoloGene: 4317 ChEMBL: 3903 GeneCards: MANBA Gene
EC number	3.2.1.25
Gene ontology Molecular function • beta-mannosidase activity • mannose binding Cellular component • lysosome • intracellular membrane-bounded organelle Biological process • carbohydrate metabolic process • cellular protein modification process • mannan catabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4126	110173
Ensembl	ENSG00000109323	ENSMUSG00000028164
UniProt	O00462	Q8K2I4
RefSeq (mRNA)	NM_005908	NM_027288
RefSeq (protein)	NP_005899	NP_081564
Location (UCSC)	Chr 4: 102.63 – 102.76 Mb	Chr 3: 135.49 – 135.57 Mb
PubMed search	[1]	[2]

Beta-mannosidase
Identifiers
EC number	3.2.1.25
CAS number	Template:CAS
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

Beta-mannosidase (EC 3.2.1.25, mannanase, mannase, beta-D-mannosidase, beta-mannoside mannohydrolase, exo-beta-D-mannanase, lysosomal beta A mannosidase) is an enzyme with system name beta-D-mannoside mannohydrolase, which is in humans encoded by the MANBA gene. This enzyme catalyses the following chemical reaction

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides

This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement.