Baccatin III

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Baccatin III

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Names
IUPAC name (2β,5α,7α,10α,13β)-4,10-Diacetoxy-1,7,13-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
Identifiers
ChEBI	CHEBI:32898
ChEMBL	ChEMBL288043
ChemSpider	23486966
Jmol 3D model	Interactive image
PubChem	65366
SMILES CC1=C2[C@@H](C(=O)[C@@]3([C@@H](C[C@H]4[C@]([C@H]3[C@H]([C@@](C2(C)C)(C[C@H]1O)O)OC(=O)c5ccccc5)(CO4)OC(=O)C)O)C)OC(=O)C
Properties
Chemical formula	C31H38O11
Molar mass	586.62677 Da
Melting point	229 to 234 °C (444 to 453 °F; 502 to 507 K)
Acidity (pKa)	12.76
Vapor pressure	{{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Baccatin III is an isolate of the Pacific yew tree (Taxus brevifolia) and related species. Baccatin III is a precursor to the anti-cancer drug paclitaxel (Taxol).

In 2014, researchers reported introduction and expression of the endophytic fungal gene responsible for synthesizing baccatin III (10-deacetylbaccatin III 10-O-acetyltransferase), to the mushroom Flammulina velutipes. Researchers achieved the same acccoplishment with Escherichia coli in 2000.

See also

• 10-Deacetylbaccatin
• Taxadiene