Arachidonate 5-lipoxygenase inhibitor
Arachidonate 5-lipoxygenase inhibitors are compounds that slow or stop the action of the arachidonate 5-lipoxygenase (5-lipoxygenase or 5-LOX) enzyme, which is responsible for the production of inflammatory leukotrienes. The overproduction of leukotrienes is a major cause of inflammation in asthma and allergic rhinitis.[1]
Examples of 5-LOX inhibitors include drugs, such as meclofenamate sodium[2] and zileuton.[2][3]
Some chemicals found in trace amounts in food, and some dietary supplements, also have been shown in inhibit 5-LOX, such as baicalein,[2] caffeic acid,[2] curcumin,[2] hyperforin[4][5][6] and St John's wort.[4][5][6]
See also
References
- ↑ David L. Nelson, Michael M. Cox. Lehninger's Principles of Biochemistry, Fifth Edition. W.H. Freeman and Co., 2008, p. 359.
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External links
- Lipoxygenase inhibitors at the US National Library of Medicine Medical Subject Headings (MeSH)
- MeSH list of agents 82016859
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