ABCB4
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Multidrug resistance protein 3 is a protein that in humans is encoded by the ABCB4 gene.[1][2][3] ABCB4 is associated with progressive familial intrahepatic cholestasis type 3.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate (flippase activity). The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.[3]
References
Further reading
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External links
- ABCB4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- ABCB4 human gene location in the UCSC Genome Browser.
- ABCB4 human gene details in the UCSC Genome Browser.
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