4'-Dimethylamino-7,8-dihydroxyflavone

4'-Dimethylamino-7,8-dihydroxyflavone
Systematic (IUPAC) name
	2-[4-(Dimethylamino)phenyl]-7,8-dihydroxy-4H-chromen-4-one
Identifiers
CAS Number	1205548-04-4
ATC code	None
ChemSpider	26630138
Chemical data
Formula	C17H15NO4
Molecular mass	297.3053 g/mol
	SMILES CN(C)c1ccc(cc1)c2cc(=O)c3ccc(c(c3o2)O)O ;
	InChI InChI=InChI=1S/C17H15NO4/c1-18(2)11-5-3-10(4-6-11)15-9-14(20)12-7-8-13(19)16(21)17(12)22-15/h3-9,19,21H,1-2H3 ; Key:YPAYCZOHGRSGJS-UHFFFAOYSA-N ;

4'-Dimethylamino-7,8-dihydroxyflavone (4'-DMA-7,8-DHF) is a synthetic flavone and selective small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF), that was derived from structural modification of 7,8-dihydroxyflavone (7,8-DHF).^[1]^[2]^[3]^[4] Relative to 7,8-DHF, 4'-DMA-7,8-DHF possesses higher agonistic activity at TrkB, is significantly more potent than 7,8-DHF both in vitro and in vivo, and has a longer duration of action (peaking at 4 hours and partially decaying at 8~16 hours).^[1]^[3] The compound has been found to produce neuroprotective, neurogenic, and antidepressant-like effects in animals.^[1]^[3]^[4]^[5]

References

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