Transforming growth interacting factor

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Transforming growth interacting factor (TGIF) is a potential repressor of TGF-β pathways in myometrial cells.^[1] Expression of TGIF is increased in uterine leiomyoma compared with myometrium.^[1]

References

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Cell signaling: TGFβ signaling pathway

TGF beta superfamily of ligands

TGF beta family	TGF-β1 TGF-β2 TGF-β3
Bone morphogenetic proteins	BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 BMP8a BMP8b BMP10 BMP15
Growth differentiation factors	GDF1 GDF2 GDF3 GDF5 GDF6 GDF7 Myostatin/GDF8 GDF9 GDF10 GDF11 GDF15
Other	Activin and inhibin Anti-müllerian hormone Nodal

TGF beta receptors
(Activin, BMP)

TGFBR1:	Activin type 1 receptors ACVR1 ACVR1B ACVR1C ACVRL1 BMPR1 BMPR1A BMPR1B
TGFBR2:	Activin type 2 receptors ACVR2A ACVR2B AMHR2 BMPR2
TGFBR3:	betaglycan

Transducers/SMAD

Ligand inhibitors

BAMBI
Cripto

Other

SARA

TGFβ receptor superfamily modulators

ALK1 (ACVRL1)	Agonists: Activin (A, B, AB) BMP (9, 10) TGFβ (1, 2, 3 (avotermin)) Antibodies: Ascrinvacumab Kinase inhibitors: K-02288 ML-347 (LDN-193719, VU0469381) Decoy receptors: Dalantercept
ALK2 (ACVR1A)	Agonists: Activin (A, B, AB) AMH (MIS) BMP (5, 6, 7 (eptotermin alfa), 8A, 8B) TGFβ (1, 2, 3 (avotermin)) Kinase inhibitors: DMH-1 DMH-2 Dorsomorphin (BML-275) K-02288 ML-347 (LDN-193719, VU0469381)
ALK3 (BMPR1A)	Agonists: AMH (MIS) BMP (2 (dibotermin alfa), 4, 5, 6, 7 (eptotermin alfa), 8A, 8B) Kinase inhibitors: DMH-2 Dorsomorphin (BML-275) K-02288
ALK4 (ACVR1B)	Agonists: Activin (A, B, AB) GDF (1, 3, GDF11) Myostatin (GDF8) Nodal Antagonists: Inhibin (A, B) Lefty (1, 2) Kinase inhibitors: A 83-01 SB-431542 SB-505124
ALK5 (TGFβR1)	Agonists: GDF (11) TGFβ (1, 2, 3 (avotermin)) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388 LY-364947 LY-2109761 Galunisertib (LY-2157299) R-268712 RepSox (E-616452, SJN-2511) SB-431542 SB-505124 SB-525334 SD-208
ALK6 (BMPR1B)	Agonists: BMP (2 (dibotermin alfa), 4, 5, 6, 7 (eptotermin alfa), 8A, 8B, 15 (GDF9B)) GDF (5, 6, 7, 9, 15) Kinase inhibitors: DMH-2 Dorsomorphin (BML-275) K-02288
ALK7 (ACVR1C)	Agonists: GDF (1, 3, 11) Nodal Antagonists: Lefty (1, 2) Kinase inhibitors: A 83-01 SB-431542 SB-505124

TGFβR2	Agonists: TGFβ (1, 2, 3 (avotermin)) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947
BMPR2	Agonists: BMP (2 (dibotermin alfa), 4, 6, 7 (eptotermin alfa), 9, 10) GDF (5, 6, 7) Antagonists: Inhibin (A, B)
ACVR2A (ACVR2)	Agonists: Activin (A, B, AB) BMP (2 (dibotermin alfa), 4, 5, 6, 7 (eptotermin alfa), 8A, 8B, 15 (GDF9B)) GDF (1, 3, 5, 6, 7, 9, 11, 15) Myostatin (GDF8) Nodal Antagonists: Inhibin (A, B) Lefty (1, 2) Decoy receptors: Sotatercept
ACVR2B	Agonists: Activin (A, B, AB) BMP (2 (dibotermin alfa), 4, 6, 7 (eptotermin alfa)) GDF (1, 3, 5, 6, 7) Myostatin (GDF8) Nodal Antagonists: Inhibin (A, B) Lefty (1, 2) Decoy receptors: Ramatercept
AMHR2 (AMHR)	Agonists: AMH (MIS)

TGFβR3 (β-glycan)	Ligands: Inhibin (A, B) TGFβ (1, 2, 3 (avotermin))

Unsorted

Endogenous antagonists/inhibitors: BAMBI
Cerberus (CER1)
Chordin
DAN (PARN)
Decorin
Follistatin
Gremlin (Drm)
LTBP1
Noggin
TGIF
Thrombospondin 1 (THBS1)
Tomoregulin 1

Antibodies: Stamulumab (against myostatin)
TRC105 (against endoglin)

See also: Growth factor receptor modulators
Cytokine receptor modulators
Peptide receptor modulators

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TGFβ domain

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